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Did you mean scn and lung (144 results)?
Sulforaphane attenuates pulmonary fibrosis by inhibiting the epithelial-mesenchymal transition.
Kyung SY, Kim DY, Yoon JY, Son ES, Kim YJ, Park JW, Jeong SH. Kyung SY, et al. BMC Pharmacol Toxicol. 2018 Apr 2;19(1):13. doi: 10.1186/s40360-018-0204-7. BMC Pharmacol Toxicol. 2018. PMID: 29609658 Free PMC article.
The BLM-induced fibrosis was characterized by western blotting and immunohistochemical analyses for fibronectin, TGF-beta1, E-cadherin (E-cad), and alpha-smooth muscle actin (SMA) in lung tissues. RESULTS: SFN reversed mesenchymal-like changes induced by TGF-beta1 a …
The BLM-induced fibrosis was characterized by western blotting and immunohistochemical analyses for fibronectin, TGF-beta1, E-cadherin (E-ca …
USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction.
Kim MJ, Min Y, Jeong SK, Son J, Kim JY, Lee JS, Kim DH, Lee JS, Chun E, Lee KY. Kim MJ, et al. Cell Death Dis. 2022 Apr 14;13(4):348. doi: 10.1038/s41419-022-04808-7. Cell Death Dis. 2022. PMID: 35422093 Free PMC article.
Herein, we provide novel molecular and cellular mechanisms involved in the negative effect of ubiquitin-specific peptidase 15 (USP15) on lung cancer progression. Clinical data of the TCGA and primary non-small cell lung cancer (NSCLC) patients (n = 41) revealed that …
Herein, we provide novel molecular and cellular mechanisms involved in the negative effect of ubiquitin-specific peptidase 15 (USP15) on …
Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis.
Zhang Z, Qu J, Zheng C, Zhang P, Zhou W, Cui W, Mo X, Li L, Xu L, Gao J. Zhang Z, et al. Cell Death Dis. 2018 Jan 23;9(2):83. doi: 10.1038/s41419-017-0198-x. Cell Death Dis. 2018. PMID: 29362432 Free PMC article.
We found BLM-induced lung fibrosis were more severe in Nrf2(-/-) mice compared to WT mice with reduced expressions of HO-1 and NQO1. ...Transfected with Nrf2 and Numb siRNAs further aggravated and relieved the progression of EMT, respectively. Inversely, activating Nrf2 pa …
We found BLM-induced lung fibrosis were more severe in Nrf2(-/-) mice compared to WT mice with reduced expressions of HO-1 and NQO1. …
DNA hypomethylation-related overexpression of SFN, GORASP2 and ZYG11A is a novel prognostic biomarker for early stage lung adenocarcinoma.
Husni RE, Shiba-Ishii A, Nakagawa T, Dai T, Kim Y, Hong J, Sakashita S, Sakamoto N, Sato Y, Noguchi M. Husni RE, et al. Oncotarget. 2019 Feb 26;10(17):1625-1636. doi: 10.18632/oncotarget.26676. eCollection 2019 Feb 26. Oncotarget. 2019. PMID: 30899432 Free PMC article.
Although alteration of DNA methylation in advanced cancer has been extensively investigated, few data for early-stage lung adenocarcinoma are available. Here, we compared DNA methylation profiles between adenocarcinoma in situ (AIS) and early invasive adenocarcinoma using …
Although alteration of DNA methylation in advanced cancer has been extensively investigated, few data for early-stage lung adenocarci …
Significance of stratifin in early progression of lung adenocarcinoma and its potential therapeutic relevance.
Shiba-Ishii A. Shiba-Ishii A. Pathol Int. 2021 Oct;71(10):655-665. doi: 10.1111/pin.13147. Epub 2021 Jul 29. Pathol Int. 2021. PMID: 34324245 Review.
Lung cancer is the most common cause of global cancer-related mortality, and the main histological type is adenocarcinoma, accounting for 50% of non-small cell lung cancer. ...This review summarizes genetic and epigenetic abnormalities that can occur in early-stage …
Lung cancer is the most common cause of global cancer-related mortality, and the main histological type is adenocarcinoma, accounting …
Combining single-cell RNA sequencing data and transcriptomic data to unravel potential mechanisms and signature genes of the progression of idiopathic pulmonary fibrosis to lung adenocarcinoma and predict therapeutic agents.
Zhou X, Tan F, Zhang S, Zhang T. Zhou X, et al. Funct Integr Genomics. 2023 Nov 24;23(4):346. doi: 10.1007/s10142-023-01274-y. Funct Integr Genomics. 2023. PMID: 37996625
Patients with idiopathic pulmonary fibrosis (IPF) have a significantly higher prevalence of lung adenocarcinoma (LUAD) than normal subjects, although the underlying association is unclear. ...Through the machine learning algorithms, we further fished TRIM2, S100A14, CYP4B1 …
Patients with idiopathic pulmonary fibrosis (IPF) have a significantly higher prevalence of lung adenocarcinoma (LUAD) than normal su …
Pulmonary granulomatosis of genetic origin.
Bode SFN, Rohr J, Müller Quernheim J, Seidl M, Speckmann C, Heinzmann A. Bode SFN, et al. Eur Respir Rev. 2021 Apr 29;30(160):200152. doi: 10.1183/16000617.0152-2020. Print 2021 Jun 30. Eur Respir Rev. 2021. PMID: 33927005 Free PMC article. Review.
Granulomatous inflammation of the lung can be a manifestation of different conditions and can be caused by endogenous inflammation or external triggers. ...Based on a detailed patient history, physical examination and a diagnostic approach including laboratory workup, pulm …
Granulomatous inflammation of the lung can be a manifestation of different conditions and can be caused by endogenous inflammation or …
Machine learning-based identification of CYBB and FCAR as potential neutrophil extracellular trap-related treatment targets in sepsis.
You G, Zhao X, Liu J, Yao K, Yi X, Chen H, Wei X, Huang Y, Yang X, Lei Y, Lin Z, He Y, Fan M, An Y, Lu T, Lv H, Sui X, Yi H. You G, et al. Front Immunol. 2023 Oct 13;14:1253833. doi: 10.3389/fimmu.2023.1253833. eCollection 2023. Front Immunol. 2023. PMID: 37901228 Free PMC article.
Of these, CYBB and FCAR were independent predictors of poor survival in patients with sepsis. Administration of SFN significantly alleviated murine lung NETs expression and injury, accompanied by whole blood CYBB mRNA level. CONCLUSION: CYBB and FCAR may be reliable …
Of these, CYBB and FCAR were independent predictors of poor survival in patients with sepsis. Administration of SFN significantly all …
Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage.
Arakawa N, Ushiki A, Abe M, Matsuyama S, Saito Y, Kashiwada T, Horimasu Y, Gemma A, Tatsumi K, Hattori N, Tsushima K, Miyashita K, Saito K, Nakamura R, Toyoda T, Ogawa K, Sato M, Takamatsu K, Mori K, Nishiya T, Izumi T, Ohno Y, Saito Y, Hanaoka M. Arakawa N, et al. Nat Commun. 2022 Oct 4;13(1):5854. doi: 10.1038/s41467-022-33160-9. Nat Commun. 2022. PMID: 36195613 Free PMC article.
SFN is also increased in serum from patients with idiopathic DAD, and in lung tissues and bronchoalveolar lavage fluid of patients with DAD. In vitro analysis using cultured lung epithelial cells suggests that extracellular release of SFN occurs via p5 …
SFN is also increased in serum from patients with idiopathic DAD, and in lung tissues and bronchoalveolar lavage fluid of pati …
Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity.
Jiang LL, Zhou SJ, Zhang XM, Chen HQ, Liu W. Jiang LL, et al. Biomed Pharmacother. 2016 Mar;78:74-80. doi: 10.1016/j.biopha.2015.11.007. Epub 2016 Jan 14. Biomed Pharmacother. 2016. PMID: 26898427
However, the effects of SFN on lung cancer have not been investigated. In this study, we investigate the chemopreventive role of SFN through the inhibition of histone deacetylase (HDAC) in two different lung cancer cells by in vitro and in vivo mouse m …
However, the effects of SFN on lung cancer have not been investigated. In this study, we investigate the chemopreventive role …
168 results